Table 1

Summary of components of the EOC risk model

RF groupRF categoryComments
FHExplicit FH of ovarian and other cancers (breast, prostate, male breast and pancreatic)Considers families of arbitrary size and structure, including affected and unaffected relatives
SexSex of all family members
AgeAges at cancer diagnosis or current ages/age at death of family members
Genetic factors
 Rare truncating/pathogenic variantsBRCA1
 Common genetic variantsPolygenic Risk ScoreExplaining 5% of the polygenic variance
 Unobserved genetic effectsResidual polygenic componentAccounts for the residual familial aggregation of EOC
HeightMeasured in cm (five categories)
Body Mass IndexMeasured in kg/m2 (three categories)
ParityNumber of live births (three categories)
Use of oral contraceptionYears of use (five categories)
Use of hormone replacement therapyNever/ever
Tubal ligationYes/no
Breast tumour pathologyOestrogen, progesterone, HER2 receptor, CK14, CK5/6 statusAs implemented in the BOADICEA breast cancer model
Demographic factors
 Country of originCountryDefines the underlying incidences used
 Birth cohortDefined by the person’s year of birthEight calendar year-specific sets of incidences
 Family ethnicityAshkenazi Jewish origin
  • BOADICEA, Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm; EOC, epithelial tubo-ovarian cancer; FH, family history; RF, risk factor.