Table 2

pLI of cohesin genes shows mutation intolerance

pLIpLI >0.9
Cohesin RAD21 0.99701Y
RAD21-AS1 NANA
SMC1A 1Y
SMC3 1Y
STAG1 1Y
STAG2 1Y
Cohesin
(Meiosis-only)
RAD21L1 4.5316×10–6 N
REC8 5.5411×10–6 N
SMC1B 0.1041N
STAG3 8.7188×10–13 N
Cohesin-support CTCF 0.99994Y
MAU2 1Y
NIPBL 1Y
PDS5A 1Y
PDS5B 1Y
WAPL/WAPAL 1Y
  • The main set of genes comprising cohesin and cohesin-support are all pLI>0.9. However, the subset of cohesin genes specific to meiosis are not pLI.

  • pLI, loss-of-function intolerance.