LC 1/posterior phenotype | LC 2/anterior phenotype | ||
Cases in LC (n) | 88 | 201 | |
Mean probability of class membership | 0.91 (0.88–0.94) | 0.96 (0.95–0.97) | |
Phenotypes | % of cases in class | ||
Hand | Preaxial polydactyly | 15.91% | 52.74%* |
Postaxial polydactyly | 96.59% | 40.80%* | |
Syndactyly | 12.50% | 53.73%* | |
Foot | Preaxial polydactyly | 45.45% | 95.52%* |
Postaxial polydactyly | 69.32% | 1.49%* | |
Syndactyly | 23.86% | 83.08%* | |
Cranium | Macrocephaly | 29/60 | 54/162 |
Hypertelorism | 23/56 | 68/177 | |
Corpus callosum | 8/44 | 8/98 | |
Genotypes | Cases (n) | ||
Total | 85/88 | 173/201 | |
Included mutations | Frameshift | 52 | 54 |
Nonsense | 26 | 42 | |
Missense | 6 | 54* | |
Splice | 1 | 23* |
*P<0.00.