Exponent score for evidence elements | Exponent sum | Overall (posterior) probability of pathogenicity (%) | UK-ACGS descriptor |
Towards pathogenicity: 8 (very strong), 4 (strong), 2 (moderate), 1 (supporting) towards benignity: −4 (strong), −1 (supporting) | |||
4+1 | 5 | 0.812 (81.2) | Hot VUS |
2+2+1 | |||
2+1+1+1 | |||
1+1+1+1+1 | |||
4 | 4 | 0.675 (67.5) | Warm VUS |
2+2 | |||
2+1+1 | |||
1+1+1+1 | |||
2+1 | 3 | 0.500 (50.0) | Tepid VUS |
1+1+1 | |||
2 | 2 | 0.325 (32.5) | Cool VUS |
1+1 | |||
1 | 1 | 0.188 (18.8) | Ice-cold VUS |
UK-ACGS, UK Association for Clinical Genomic Science; VUS, variant of uncertain significance.