Evidence elements for pathogenicity | Evidence elements for benignity | Net exponent score | CanVIG-UK assignation of variant class |
Towards pathogenicity: 8 (very strong), 4 (strong), 2 (moderate), 1 (supporting); towards benignity: −4 (strong), −1 (supporting) | |||
8+4 | (−1) | 11 | Likely pathogenic |
8+4 | (−1)+(−1) | 10 | VUS |
8+4 | (−4) | 8 | VUS |
4+4 | (−1) | 7 | Likely pathogenic |
4+4+1 | (−1)+(−1) | 7 | VUS |
1 | (−4) | -3 | Likely benign |
1+1 | (−4)+(−4) | -6 | VUS |
CanVIG-UK, Cancer Variant Interpretation Group UK; VUS, Variant of Uncertain Significance.