Table 7

Examples of potential combinations of conflicting evidence and the resultant CanVIG-UK classification that would be given

Evidence elements for pathogenicityEvidence elements for benignityNet exponent scoreCanVIG-UK assignation of variant class
Towards pathogenicity: 8 (very strong), 4 (strong), 2 (moderate), 1 (supporting);
towards benignity: −4 (strong), −1 (supporting)
8+4(−1)11Likely pathogenic
8+4(−1)+(−1)10VUS
8+4(−4)8VUS
4+4(−1)7Likely pathogenic
4+4+1(−1)+(−1)7VUS
1(−4)-3Likely benign
1+1(−4)+(−4)-6VUS
  • CanVIG-UK, Cancer Variant Interpretation Group UK; VUS, Variant of Uncertain Significance.