Table 5

Maximum number of evidence elements attainable by variant type using the CanVIG-UK specification

Variant typeMaximum number of pieces of evidence at each strength
PathogenicityBenignity
Very strongStrongModerateSupportingSupportingStrongStandalone
Truncating4789451
Missense37912651
In-frame indel36910551
Synonymous3679651
  • PP5 and BP6 (reputable source) are permitted by the CanVIG-UK specification 2020 at supporting level and so are included in the totals above, despite not being permitted by Brnich et al19

  • CanVIG-UK, Cancer Variant Interpretation Group UK.