Variant type | Maximum number of pieces of evidence at each strength | ||||||
Pathogenicity | Benignity | ||||||
Very strong | Strong | Moderate | Supporting | Supporting | Strong | Standalone | |
Truncating | 4 | 7 | 8 | 9 | 4 | 5 | 1 |
Missense | 3 | 7 | 9 | 12 | 6 | 5 | 1 |
In-frame indel | 3 | 6 | 9 | 10 | 5 | 5 | 1 |
Synonymous | 3 | 6 | 7 | 9 | 6 | 5 | 1 |
PP5 and BP6 (reputable source) are permitted by the CanVIG-UK specification 2020 at supporting level and so are included in the totals above, despite not being permitted by Brnich et al19
CanVIG-UK, Cancer Variant Interpretation Group UK.