Demographic and clinical features of included patients and associations with diagnostic outcome
Characteristics | n (%) | Genetically solved/unsolved cases |
Sex | ||
Male | 48 (43) | 6/42 |
Female | 64 (57) | 7/57 |
Median age at seizure onset, years (range) | 15 (1–67) | 9/15 (median)* |
Seizure focus | ||
Temporal | 57 (51) | 4/53 |
Frontal | 27 (24) | 5/22 |
Parietal | 2 (2) | 0/2 |
Occipital | 2 (2) | 2/0 |
Unclassified | 24 (21) | 2/22 |
MRI | ||
Normal | 101 (90) | 12/89 |
Hippocampal sclerosis/atrophy | 11 (10) | 1/10 |
Family history | ||
Positive (at least one first-degree or two second-degree relatives with seizures) | 37 (33) | 6/31 |
Negative | 75 (67) | 7/68 |
History of FS | ||
Yes | 10 (9) | 1/9 |
No | 102 (91) | 12/90 |
AED response | ||
Responsive | 6 (5) | 0/6 |
Resistant | 86 (77) | 10/76 |
Undefined | 20 (18) | 3/17 |
*Statistically significant, Mann-Whitney U-test: uncorrected p value=0.01.
AED, antiepileptic drug; FS, febrile seizure.