Patient groups analysed | Rare variant group | Difference (%) | Adjusted P value |
FHM versus familial migraine | Functional variants | 15.1 | 1.46e-6 |
FHM versus sporadic migraine | Functional variants | 17.5 | 5.2e-10 |
Sporadic migraine versus familial migraine | Functional variants | 2.2 | 0.0076 |
FHM versus familial migraine | Frameshift indels | 13.2 | 0.00099 |
Non-frameshift indels | 2.3 | 1 | |
Stop codon indels | −0.5 | 1 | |
Non-synonymous SNP | 11.8 | 0.0038 | |
FHM versus sporadic migraine | Frameshift indels | 20 | 5.19e-13 |
Non-frameshift indels | 4.4 | 0.13 | |
Stop codon indels | 2.1 | 1 | |
Non-synonymous SNP | 20.1 | 1.60e-13 |
The results from the MCMCgrm area under the curve analysis are listed in columns 3 and 4, where the differences (%) between groups are listed, together with the adjusted p values, respectively.
FHM, familial hemiplegic migraine; SNP, Single Nucleotide Polymorphism.