Table 3

Characteristics of studies that examined MDM2 SNP rs2279744

Reference	OR (95% CI)	P values	EAF	Ancestry	Cases (n)	Controls (n)	EC type	Dataset(s)
Terry 200848	1.32 (1.11 to 1.56)	0.002	N/A	European	591	1543	N/A	NHS (Nurses’ Health Study), WHS (Women’s Health Study)
Ashton 200949	1.37 (1.06 to 1.79)	N/A	0.56	Caucasian	191	291	All	Hospital based
Nunobiki 200950	2.28 (2.02 to 2.54)	0.030	0.49	Japanese	102	95	All	Hospital based
Ueda 200951	1.91 (1.5 to 3.47)	0.035	0.51	Japanese	119	108	All	Hospital based
Wan 201143	1.54 (1.21 to 1.94)	0.000	N/A	N/A	N/A	N/A	N/A	Walsh 2007,36 Terry 2008, Ashton 2009, Nunobiki 2009, Ueda 2009
Li 201144	1.75 (1.16 to 2.63)	0.007	N/A	European, Asian	1001	1889	N/A	Walsh 2007, Terry 2008, Ashton 2009, Nunobiki 2009, Ueda 2009
Knappskog 201240	1.22 (1.03 to 1.44)	N/A	0.36	European	392	956	N/A	Hospital based
Zajac 201227	1.33 (1.12 to 1.58)	0.001	N/A	European	152	100	N/A	Hospital based
Yoneda 201352	1.64 (0.81 to 3.28)	0.450	0.45	Asian	125	200	All	Population based
Peng 201341	1.6 (1.21 to 2.13)	0.001	N/A	European, Asian	2069	4546	N/A	Walsh 2007, Terry 2008, Ashton 2009, Nunobiki 2009, Knappskog 2012, Yoneda 2013
Peng 201341	1.87 (1.29 to 2.73)	0.010	N/A	European	1842	4251	N/A
Zhao 201453	1.41 (1.04 to 1.92)	0.030	N/A	European, Asian	1278	2189	N/A	Walsh 2007, Terry 2008, Ashton 2009, Ueda 2009, Zajac 2012, Yoneda 2013
Zhao 201453	1.34 (1.07 to 1.69)	N/A	N/A	European	859	1707	N/A
Wang 201438	1.32 (1.06 to 1.64)	0.010	N/A	European, Asian	1967	4460	N/A	Walsh 2007, Terry 2008, Ashton 2009, Nunobiki 2009, Ueda 2009, Zajac 2012, Knappskog 2012, Yoneda 2013
Wang 201438	1.14 (0.79 to 1.65)	0.490	N/A	European	1769	4172	N/A
Xue 201642	1.46 (1.25 to 1.72)	N/A	N/A	European	1690	4151	N/A	Walsh 2007, Terry 2008, Ashton 2009, Nunobiki 2009, Ueda 2009, Zajac 2012, Knappskog 2012, Yoneda 2013
Zhang 201854	1.91 (1.5 to 3.47)	0.035	N/A	European, Asian	762	1041	N/A	Walsh 2007, Terry 2008, Ashton 2009, Nunobiki 2009, Ueda 2009, Zajac 2012
Zou 201855	1.23 (1.06 to 1.41)	0.005	N/A	European, Asian, mixed	3535	6476	All	Walsh 2007, Terry 2008, Ashton 2009, Ueda 2009, Knappskog 2012, Zajac 2012, Yoneda 2013, Okamoto 2015, Gansmo 201737

*Walsh et al 2007 and Gansmo et al 2017 did not meet eligibility criteria for us to include in our evaluation.
EAF, effect allele frequency; EC, endometrial cancer; SNP, single nucleotide polymorphism.