Table 2

Frequency of mutations and estimated risk of EOC in candidate genes for validation chip genotyping data

Set*HistotypeGeneControlsCasesOR (95% CI)P value
No.%No.%
OCACOverallPALB260.03110.082.10 (0.74 to 5.94)0.16
Non-carrier18 93099.9713 27799.9
HGSOCPALB260.0360.0973.48 (1.10 to 11.1)0.035
Non-carrier18 93099.97616899.9
BiobankOverallPALB2110.1130.353.12 (0.87 to 11.2)0.081
POLK290.3020.230.78 (0.19 to 3.29)0.74
Non-carrier968599.685399.4
HGSOC†PALB2110.1110.282.49 (0.32 to 19.4)0.38
POLK290.3010.280.92 (0.12 to 6.74)0.93
Non-carrier968599.636199.4
  • *OCAC: OCAC sample genotype on the OncoArray; Biobank: genotype from UK Biobank Axiom Array.

  • †Information on tumour grade was not available for UK Biobank cases, all the serous cases in UK Biobank were assumed to be HGSOC.

  • EOC, epithelial ovarian cancer.