Table 1

Number of alleles with mutations within AIS-associated genes in individuals with AIS and controls

Patients with mutations >1 (n)OR (95% CI)
(AIS vs controls)
P value
(AIS vs controls)
AIS (n=223)371
1000 Genomes Project controls (n=222)85.321 (2.417 to 11.714)6.00E-06
In-house controls (n=153)39.946 (3.008 to 32.893)2.00E-06
Combined controls (n=375)116.583 (3.282 to 13.201)7.44E-09
  • AIS, adolescent idiopathic scoliosis.