Table 4

Risk factors and their effect on curve progression by univariate Cox proportional hazard regression analyses

CharacteristicsPatients (n)HR (95% CI)P value
Sex
 Male241
 Female1991.197 (0.593 to 2.415)6.16E-01
Age of curve onset (years)
 ≤121271
 >12960.661 (0.406 to 1.077)9.70E-02
Curve magnitude at first presentation (°)
 ≤231301
 >23932.137 (1.324 to 3.448)2.00E-03
Risser sign
 ≤21231
 >21000.871 (0.545 to 1.393)5.65E-01
Body mass index (kg/m2)
 ≤21.96861
 >21.961370.680 (0.426 to 1.084)1.05E-01
Lenke classification
 1231
 21101.290 (0.503 to 3.308)5.96E-01
 3281.274 (0.403 to 4.025)6.80E-01
 4272.562 (0.906 to 7.244)7.60E-02
 5291.889 (0.640 to 5.572)2.49E-01
 661.992 (0.384 to 10.372)4.12E-01
Number of rare damaging variants
 ≤11861
 >1375.098 (3.121 to 8.328)7.69E-11