Table 3

Performance on key measures of seven cognitive tasks by male and female deletion carriers and controls

Cognitive taskControl groupDeletion groupStatistical comparisonBenjamini-Hochberg corrected p value
Male participants
Pairs Matching Test (total number of errors)−0.11 (−0.11 to −0.11) (n=42 990)0.25 (−0.11 to 0.54) (n=86)B=0.202±0.112, β=0.009, p=0.0710.166
Reaction Time Test−0.19 (−0.19 to −0.18) (n=42 626)−0.025 (−0.19 to 0.265) (n=86)B=0.217±0.101, β=0.010, p=0.0320.112
Fluid Intelligence Test (total number of correct answers)0.40 (−0.07 to 0.40) (n=13 072)−0.07 (−0.55 to 0.40) (n=31)B=−0.465±0.190, β=−0.021, p=0.0140.098
Digit Span Test (maximum number of digits remembered)0.21 (0.21 to 0.21) (n=4195)0.21 (−0.165 to 0.97) (n=10)U=18 543.5, p=0.5120.563
Symbol Digit Substitution Test (number of correct substitutions)0.05 (0.05 to 0.05) (n=11 664)−0.35 (−0.838 to 0.345) (n=13)U=63 851, p=0.3230.452
Trail Making Test A (time to completion)−0.19 (−0.22 to −0.17) (n=10 580)−0.04 (−0.43 to 1.07) (n=14)U=58 547, p=0.1750.306
Trail Making Test B (time to completion)−0.11 (−0.13 to −0.10) (n=10 588)0.125 (−0.53 to 0.44) (n=14)U=67 499, p=0.5630.563
Female participants
Pairs Matching Test (total number of errors)−0.11 (−0.11 to −0.11) (n=54 151)0.25 (−0.11 to 0.25) (n=312)B=0.105±0.057, β=0.008, p=0.0670.235
Reaction Time Test0.01 (0.01 to 0.01) (n=53 692)−0.10 (−0.24 to 0.0495) (n=309)B=−0.0202±0.052, β=−0.002, p=0.6970.835
Fluid Intelligence Test (total number of correct answers)−0.07 (−0.07 to −0.07) (n=16 615)
(mean: 0.05±0.0074)
−0.07 (−0.55 to −0.07) (n=103)
(mean: −0.31±0.0972)
B=−0.352±0.096, β=−0.028, p<0.001<0.0063
Digit Span Test (maximum number of digits remembered)0.21 (0.21 to 0.21) (n=5386)0.21 (−0.54 to 0.59) (n=36)B=0.058±0.160, β=0.005, p=0.7160.835
Symbol Digit Substitution Test (number of correct substitutions)0.05 (0.05 to 0.05) (n=15 163)0.15 (−0.25 to 0.54) (n=64)B=−0.063±0.114, β=−0.004, p=0.5810.835
Trail Making Test A (time to completion)−0.02 (−0.04 to 0.00) (n=13 179)0.015 (−0.28 to 0.29) (n=58)B=0.020±0.126, β=0.001, p=0.8750.875
Trail Making Test B (time to completion)0.01 (−0.01 to 0.03) (n=13 206)0.08 (−0.17 to 0.385) (n=58)B=0.123±0.121, β=0.009, p=0.3070.716
  • Data are presented as median z-scores with 95% confidence limits.