Sample size | Average % difference in GRS (95% CI) significant iterations | Average % difference in GRS (95% CI) all iterations | % difference range (minimum–maximum) |
50 | 18.86 (18.01 to 19.71) | 6.76 (6.43 to 7.08) | 0.000–28.78 |
100 | 13.31 (12.74 to 13.89) | 4.83 (4.61 to 5.05) | 0.000–20.78 |
200 | 9.63 (9.18 to 10.08) | 3.24 (3.09 to 3.39) | 0.000–14.41 |
300 | 7.59 (7.38 to 7.80) | 2.70 (2.57 to 2.83) | 0.013–9.50 |
600 | 5.62 (5.40 to 5.83) | 1.90 (1.81 to 1.99) | 0.001–8.12 |
700 | 5.31 (5.04 to 5.58) | 1.76 (1.67 to 1.84) | 0.001–7.67 |
800 | 4.77 (4.59 to 4.95) | 1.65 (1.58 to 1.73) | 0.006–6.43 |
1000 | 4.49 (4.27 to 4.70) | 1.48 (1.41 to 1.51) | 0.003–7.77 |
2000 | 3.09 (2.96 to 3.23) | 1.06 (1.01 to 1.11) | 0.001–4.42 |
The average per cent difference between GBA trial arms and related CIs are shown for each sample size for both significant iterations and total iterations. Significant iterations were determined by Z-score cut-off scores of ±1.96 (p<0.05). Minimum and maximum per cent differences found between arms for all 1000 iterations are also shown. Data are available upon request from the database of Genotypes and Phenotypes (dbGaP).
GRS, genetic risk score.