Average per cent difference in variant dosage
| Sample size | Average % difference in GRS (95% CI) significant iterations | Average % difference in GRS (95% CI) all iterations | % difference range (minimum–maximum) |
| 200 | 41.60 (40.57 to 42.62) | 51.55 (49.01 to 54.10) | 0.079–198.76 |
| 400 | 33.80 (32.68 to 34.93) | 36.60 (34.77 to 38.42) | 0.045–179.82 |
| 600 | 91.31 (85.58 to 97.05) | 29.14 (27.67 to 30.61) | 0.024–146.82 |
| 1000 | 71.15 (66.91 to 75.39) | 22.64 (21.52 to 23.77) | 0.006–103.84 |
| 2000 | 48.03 (45.66 to 50.40) | 16.67 (15.86 to 17.48) | 0.006–86.71 |
| 3000 | 39.00 (37.45 to 40.56) | 13.91 (13.25 to 14.56) | 0.001–56.55 |
| 4000 | 35.02 (33.20 to 36.84) | 11.22 (10.69 to 11.75) | 0.016–53.26 |
| 5000 | 29.87 (28.43 to 31.31) | 10.58 (10.09 to 11.07) | 0.014–47.12 |
The average percent difference in allele dosage for each of the 47 variants used in this study between trial arms and related confidence intervals are shown for each sample size for both significant and total iteration. Significant iterations were determined by Z-score cut-off scores of ± 1.96 (p < 0.05). Minimum and maximum percent differences found between arms are also shown.
GRS, genetic risk score.