Descriptive statistics and summary of psychological outcomes
| Scale | Scale range/threshold | Study enrolment | At MRI appointment | Preresults | 12 weeks after results | 26 weeks after results | 52 weeks after results | ||||||
| Carriers (n=44) | Controls (n=44) | Carriers (n=37) | Controls (n=37) | Carriers (n=36) | Controls (n=38) | Carriers (n=29) | Controls (n=38) | Carriers (n=33) | Controls (n=38) | Carriers (n=28) | Controls (n=34) | ||
| HADS Anxiety, mean (SD); n above threshold | 0–1 | 6.2 (3.9)* | 4.9 (3.3) | – | – | 5.3 (3.9)* | 4.6 (3.3) | 5.8 (4.3) | 4.1 (3.1) | 5.9 (4.1) | 4.4 (2.9) | 5.7 (4.8) | 4.1 (3.2) |
| 0–7 | 28 | 36 | 29 | 28 | 19 | 34 | 22 | 32 | 19 | 30 | |||
| 8–10 | 10 | 5 | 3 | 9 | 5† | 1† | 7 | 5 | 5 | 2 | |||
| >10 | 6 | 3 | 4 | 1 | 5† | 3† | 2 | 1 | 4 | 2 | |||
| HADS Depression, mean (SD); n above threshold | 0–21 | 2.3 (2.5) | 2.1 (1.9) | – | – | 2.4 (2.8) | 2.3 (2.6) | 2.3 (3.3) | 1.8 (2.3) | 2.6 (2.8) | 2.3 (2.8) | 3.0 (3.8) | 2.1 (2.3) |
| 0–7 | 42 | 43 | 34 | 36 | 26 | 37 | 27 | 37 | 25 | 33 | |||
| 8–10 | 2 | 1 | 0 | 1 | 1 | 1 | 4 | 0 | 2 | 1 | |||
| >10 | 0 | 0 | 2 | 1 | 2 | 0 | 0 | 1 | 1 | 0 | |||
| CWS-R, mean (SD) | 8–32 | 14.4 (3.6)† | 12.2 (1.7)*† | – | – | – | – | 13.6 (4.4) | 12.1 (1.9) | 14.7 (4.2)† | 11.9 (1.8)† | 14.5 (4.3)† | 11.9 (1.4)*† |
| IES: cancer intrusion | 0–35 | – | – | – | – | 11.4 (9.1)*† | 3.0 (4.9)†* | 8.3 (9.1)*† | 1.8 (3.1)† | 11.0 (10.0)† | 1.7 (3.5)*† | 9.2 (8.2)† | 2.1 (3.8)† |
| 0–8 | 15 | 33 | 18 | 35 | 15 | 36 | 14 | 32 | |||||
| >8 | 21† | 5† | 10† | 3† | 16† | 2† | 13† | 2† | |||||
| IES: cancer avoidance | 0–40 | – | – | – | – | 13.3 (10.5)† | 7.0 (8.2)*† | 9.9 (9.0) † | 3.8 (5.9)*† | 13.4 (11.7)† | 4.3 (6.7)† | 10.1 (9.4)† | 2.6 (4.6)*† |
| 0–8 | 13 | 24 | 12 | 31 | 12 | 31 | 12 | 30 | |||||
| >8 | 23† | 14†* | 16† | 7*† | 19† | 7† | 15† | 4†* | |||||
| IES: MRI | 0–35 | – | – | – | – | – | – | 1.7 (3.6) | 0.5 (1.8) | 3.1 (8.8)† | 0.3 (1.4)† | 1.2 (3.2)† | 0.1 (0.3)† |
| 0–8 | 26 | 37 | 29 | 38 | 26 | 34 | |||||||
| >8 | 2 | 1 | 2 | 0 | 1 | 0 | |||||||
| IES: MRI avoidance | 0–40 | – | – | – | – | – | – | 2.8 (5.5) | 2.8 (1.8) | 4.1 (9.3)† | 0.8 (1.4)† | 1.8 (3.4) | 1.0 (0.3) |
| 0–8 | 24 | 35 | 29 | 35 | 26 | 31 | |||||||
| >8 | 4 | 3 | 2 | 3 | 1 | 3 | |||||||
| SSAI, mean (SD) | 6–24 | – | – | 7.2 (3.3) | 7.3 (3.2) | – | – | – | – | – | – | – | – |
| Health Questionnaire, mean (SD) | 0–14 | 7.0 (2.6) | 6.8 (2.2) | – | – | 8.1 (2.8)† | 6.9 (2.2)† | 7.1 (2.5) | 7.7 (2.1) | 7.2 (2.4) | 7.2 (2.2) | 7.2 (2.6) | 7.6 (1.5) |
| SF36-II physical component summary, mean (SD) | 0–100 | 49.2 (6.1)† | 52.1 (4.5)† | – | – | – | – | 50.7 (8.5) | 52.0 (5.5) | 48.4 (8.2)† | 51.7 (9.0)† | 47.9 (9.8)† | 51.7 (7.3)† |
| SF36-II mental component summary, mean (SD) | 0–100 | 50.2 (8.3)† | 54.0 (6.8)† | – | – | – | – | 50.0 (10.2) | 53.2 (9.9) | 49.3 (10.0) | 52.1 (9.5) | 49.3 (10.0) | 53.3 (8.7) |
| Risk Perception, mean (SD) | 0–100 | 68.7† (24.9) | 27.0† (17.8) | – | – | – | – | 71.2† (24.4) | 30.6† (16.4) | 70.6† (25.5) | 33.9† (18.7) | 67.7† (27.0) | 35.7† (19.4) |
*Significant difference in scores between time-points (same group) compared with baseline (first) measure.
†Significant difference in scores between groups.
CWS-R, Cancer Worry Scale Revised; HADS, Hospital Anxiety and Depression Scale; IES, Impact of Events Scale; SF36-II, Short Form-36 Health Survey V.2; SSAI, Spielberger State Anxiety Inventory.