Comparison of demographic and baseline clinical data between two groups
| Variable | Park 16 variant carriers | Non carriers | P value |
| Age at diagnosis (year), mean (SD) | 66.2 (9.5) | 64.4 (10.6) | 0.333 |
| Interval from diagnosis to baseline (year), mean (SD) | 0.1 (0.4) | 0.2 (0.5) | 0.398 |
| Years of education, mean (SD) | 5.6 (4.5) | 7.3 (4.5) | 0.05 |
| MMSE score at baseline, mean (SD) | 23.8 (4.2) | 25.2 (3.5) | 0.379 |
| H&Y stage at baseline, mean (SD) | 2.2 (0.6) | 2.2 (0.6) | 0.932 |
| UPDRS motor score at baseline, mean (SD) | 22.7 (11.8) | 21.8 (10.9) | 0.819 |
| UPDRS subscores at baseline, mean (SD) | |||
| Tremor subscore (range 0–28) | 2.2 (2.0) | 2.4 (4.0) | 0.782 |
| Rigidity subscore (range 0–20) | 6.4 (4.4) | 4.9 (2.8) | 0.326 |
| Bradykinesia subscore (range 0–36) | 11.3 (4.1) | 10.3 (4.4) | 0.510 |
| Posture and gait subscore (range 0–12) | 3.2 (1.9) | 3.2 (2.8) | 0.994 |
| Total daily LED at year 2, mean (SD) | 336.2 (169.3) | 348.5 (168.9) | 0.772 |
| Total daily LED at year 5, mean (SD) | 430.0 (207.5) | 464.8 (250.3) | 0.749 |
| Total daily LED at year 9, mean (SD) | 857.5 (337.5) | 778.3 (254.7) | 0.649 |
H&Y, Hoehn and Yahr; LED, levodopa equivalent dose; MMSE, Mini-Mental State Examination; UPDRS, Unified Parkinson’s Disease Rating Scale.