Table 3

Breast cancer risk category change in the family-based cohort

Lifetime riskIKNL18 NICE17 NCCN16
BOADICEALTR BOADICEAsPRS N% changeN% changeN% change
< 17% < 17%   10810.7  
< 17% > 17%   13  
17%–30 % 17%–30 %   31715.5  
17%–30 % < 17%   24  
17%–30 % > 30%   34  
< 20% < 20% 17514.2  17514.2
< 20% > 20% 29  29
> 20% > 20%     34310.0
> 20% < 20%     38
20%–30 % 20%–30 % 22024.7    
20%–30 % < 20% 38    
20%–30 % > 30% 34    
> 30% > 30% 7416.97416.9  
> 30% < 30% 1515  
O verall change   19.8   14.7   11.5

  • Following the Dutch IKNL guideline, cut-off levels of 20% and 30% represent low, moderate and high risk categories. Following the NICE guideline, 17% and 30% represent low, moderate and high risk categories. Following the NCCN guideline, 20% represent a cut-off level for the high-risk category.

  • BOADICEALTR, breast cancer lifetime risk at age 80, based on BOADICEA alone; BOADICEAsPRS, 161-SNP PRS based breast cancer lifetime risk score; IKNL, Netherlands Comprehensive Cancer Organisation; NCCN, National Comprehensive Cancer Network; NICE, National Institute for Health and Care Excellence.