Table 2

Significant loci associating with the circulating inflammatory phenotypes

StudyMarkerLocusChr:PositionCandidate geneNearest gene(s)AnnotationdbSNP referenceINFOEAEAFBetaP valueHetPValVariance explainedTotal variance explained
NFBC1966sE-selectin9q34.29:136 141 870ABOABOIntronicrs25190930.994T0.188−0.9034.48e-305NA0.2490.258
11q24.211:126 266 665ST3GAL4ST3GAL4Intronicrs112204710.967G0.2120.1627.72e-12NA0.009
sICAM-19q34.29:136 141 870ABOABOIntronicrs25190930.994T0.188−0.3527.43e-48NA0.0380.118
19p13.219:10 383 403ICAM1ICAM1Intronicrs1179607960.802A0.012−1.6698.03e-40NA0.066
19p13.219:10 497 360ICAM1CDC37Intergenicrs744286140.992A0.1630.2261.14e-16*NA0.014
sVCAM-19q34.29:136 131 322ABOABOMissensers81767461.000T0.1290.2565.06e-19NA0.0150.038
12q23.312:104 448 391HSP90B1GLT8D2Intronicrs1172386250.981A0.0230.5102.90e-14NA0.012
17q24.217:66 823 805ABCA8ABCA8Intergenicrs1120010350.883A0.0600.3241.04e-13NA0.012
Meta-analysesIL1β6p22.16:30 017 071HLA locusIntronicrs69176031.000C0.2510.1631.76e-121.000.0100.015
6p22.16:30 013 887HLA locusIntronicrs92612241.000T0.0350.2611.31e-09 *1.000.005
IP104q21.14:76 899 176CXCL10SAD1Intronicrs1927163150.851C0.0031.5132.71e-131.000.0140.014
MCP11q23.21:159 175 354ACKR1ACKR1Missensers120751.000A0.4690.1481.43e-331.51e-130.0110.011
TNFα13q14.313:51 141 997DLEU1DLEU1Intronicrs170745750.803G0.0022.1312.71e-091.000.0180.018
VEGF4p16.24:5 636 073STK32BEVC2Intronicrs1867253820.875A0.0012.3804.53e-101.000.0110.052
6p21.16:43 927 050VEGFAC6orf223Intergenicrs77673961.000A0.5230.2848.35e-1051.22e-690.0400.056
9p24.29:2 686 273VLDLRVLDLR, KCNV2Intergenicrs70307810.959T0.373-0.0991.57e-135.34e-040.005
  • Statistical significance is considered at p<3.1×10−9. Novel findings are highlighted with bold font. All positions correspond to human genome build 37.

  • *Indicates associations that are significant after conditioning the analyses on the locus-specific lead variant on the preceding row.

  • EA, effect allele; EAF, effect allele frequency; HLA, human leukocyte antigen; HetPVal, p value of heterogeneity as estimated by Cochrane’s Q-test; IL1β, interleukin 1-beta ; INFO, imputation score in NFBC1966; IP10, interferon gamma-induced protein 10; MCP1, monocyte chemoattractant protein 1; NA, not available; NA, not available; NFBC1966, Northern Finland Birth Cohort 1966; TNFα, tumour necrosis factor alpha; VEGF, vascular endothelial growth factor; dbSNP, single nucleotide polymorphism database; sE-selectin, soluble E-selectin; sICAM-1, soluble intercellular adhesion molecule -1; sVCAM-1, soluble vascular cell adhesion molecule-1.