CLDRC multivariate replication
| Marker | CHR | BP | Minor allele | MAF* | P value | ||||
| Joint model | RAN Pictures | RAN Colours | RAN Letters | RAN Numbers | |||||
| rs6963842† | 7 | 107 634 989 | T | 0.495 | 0.360 | 0.963 | 0.644 | 0.856 | 0.244 |
| rs1555839† | 10 | 90 382 820 | C | 0.319 | 0.018 | 0.256 | 0.019 | 2.38×10−3‡ | 0.086 |
| rs701825† | 10 | 90 417 547 | G | 0.282 | 4.60×10−3‡ | 0.562 | 4.09×10−3‡ | 9.32×10−4‡ | 0.04 |
Results from the joint analysis of RAN Colours, RAN Pictures, RAN Letters and RAN Numbers across the top associated markers from the GRaD multivariate and meta-analytic discovery analyses. Results from follow-up, independent univariate analysis of RAN Pictures, RAN Colours, RAN Letters and RAN Numbers at each marker are also represented.
*MAF based on allele frequencies within the CLDRC sample.
†Imputed markers.
‡Survives Bonferroni correction for multiple testing (p<0.05/3=0.0161).
BP, base position; CHR, chromosome; CLDRC, Colorado Learning Disability Research Center; GRaD, Genes, Reading, and Dyslexia study; MAF, minor allele frequency; RAN, rapid automatised naming.