Table 1

Multivariate genome-wide association study results

MarkerCHRBPMinor alleleMAFP valueGene
Joint modelRAN ObjectsRAN LettersRAS Letters/Numbers
rs15558391090 382 820C0.16*4.03×10−87.06×10−5 6.20×10−6 1.71×10−9 RPL7P34
rs79137421090 376 864C0.1492.89×10−7 2.94×10−4 3.01×10−5 1.33×10−8 RPL7P34
rs107495931090 374 057C0.1533.04×10−7 4.30×10−4 2.21×10−5 1.31×10−8 RPL7P34
rs113424746192 920 806A0.0563.49×10−7 8.83×10−5 9.73×10−5 0.334 lnc-ZNF77-1
rs7018251090 417 547G0.1327.92×10−7 5.47×10−4 1.35×10−6 6.15×10−8
rs69638427107 634 989G0.4718.57×10−7 2.43×10−4 1.84×10−7 2.08×10−6 LAMB1
  • Top associated markers with p<1×10−6 in the GRaD study that were identified using a joint model of RAN Objects, RAN Letters and RAS Letters/Numbers. Results from follow-up, independent univariate analysis of RAN Objects, RAN Letters and RAS Letters/Numbers at each marker are also represented. Markers were assigned to genes if they fell within the canonical gene body as described by 1000 Genomes Project Phase 3 (V.80 GRCh37).

  • *For self-reported African–Americans in the GRaD sample, rs1555839 has a MAF of 0.129. For self-reported Hispanic Americans, the MAF of rs1555839 is 0.178.

  • †Genome-wide significant (p<5×10−8).

  • BP, base position; CHR, chromosome; GRaD, Genes, Reading, and Dyslexia study; MAF, minor allele frequency; RAN, rapid automatised naming.