Genes | Effective residue | PLINK INFO | ERF (%) | OR (95% CI) | P values | ||
Cases (n=1468) | Controls (n=1490) | Europeans* | |||||
HLA-A | Arg151 | 0.99 | 19.6 | 29.6 | 11.5 | 0.58 (0.51 to 0.65) | 1.71×10−18 |
HLA-B | Lys66-Arg69-Val76 | 0.95 | 14.1 | 6.5 | – | 2.38 (2.00 to 2.87) | 5.81×10−21 |
HLA-C | Tyr116 | 1.03 | 37.9 | 27.8 | 10.9 | 1.59 (1.41 to 1.76) | 1.15×10−15 |
HLA-DPA1 | Met11 | 0.92 | 59.5 | 44.8 | 3.5 | 1.90 (1.70 to 2.12) | 1.76×10−31 |
HLA-DPB1 | Leu35 | 0.93 | 50.9 | 36.6 | 9.4 | 1.80 (1.72 to 2.15) | 8.73×10−29 |
HLA-DQA1 | Lys47- His52-Leu54 | 1.04 | 7.0 | 15.2 | 12.9 | 0.42 (0.36 to 0.51) | 1.93×10−21 |
HLA-DQB1 | Ala-10 | 0.98 | 86.9 | 78.9 | 82.4 | 1.78 (1.55 to 2.04) | 1.18×10−15 |
HLA-DQB1 | Asp57 | 0.96 | 72.7 | 63.6 | 54.7 | 1.53 (1.37 to 1.71) | 1.79×10−13 |
HLA-DRB1 | Gly11-Tyr13-Lys14-Gln25-Leu30-Gln74 | 1.04 | 7.1 | 15.2 | 10.3 | 0.42 (0.36 to 0.51) | 1.93×10−21 |
*Amino acid residue frequencies of Europeans from the Hapmap CEU population.14
ERF, effective residue frequency; HLA, human leucocyte antigen.