Table 1

Associations of HLA amino acid residues with Graves’ disease risk in Han Chinese

GenesEffective residuePLINK INFOERF (%)OR (95% CI)P values
Cases (n=1468)Controls (n=1490)Europeans*
HLA-AArg1510.9919.629.611.50.58 (0.51 to 0.65)1.71×10−18
HLA-BLys66-Arg69-Val760.9514.16.52.38 (2.00 to 2.87)5.81×10−21
HLA-CTyr1161.0337.927.810.91.59 (1.41 to 1.76)1.15×10−15
HLA-DPA1Met110.9259.544.83.51.90 (1.70 to 2.12)1.76×10−31
HLA-DPB1Leu350.9350.936.69.41.80 (1.72 to 2.15)8.73×10−29
HLA-DQA1Lys47- His52-Leu541.047.015.212.90.42 (0.36 to 0.51)1.93×10−21
HLA-DQB1Ala-100.9886.978.982.41.78 (1.55 to 2.04)1.18×10−15
HLA-DQB1Asp570.9672.763.654.71.53 (1.37 to 1.71)1.79×10−13
HLA-DRB1Gly11-Tyr13-Lys14-Gln25-Leu30-Gln741.047.115.210.30.42 (0.36 to 0.51)1.93×10−21
  • *Amino acid residue frequencies of Europeans from the Hapmap CEU population.14

  • ERF, effective residue frequency; HLA, human leucocyte antigen.