Table 3

Association of the HLA amino acid positions with Graves’ disease risk in Han Chinese

HLA variantFrequency (%)*OR (95%  CI) †P values†
Case (n=1468)Control (n=1490)
HLA-DPβ1 amino acid position 205
 Met45.132.41.88 (1.67 to 2.12)1.18×10−2
 Deletion3.89.10.40 (0.32 to 0.5)3.32×10−15
 Val51.158.5(reference)
HLA-B amino acid position 66
 Lys14.16.52.39 (2.00 to 2.87)4.42×10−13
 Asn5.06.50.76 (0.61 to 0.95)6.17×10−2
 Ile80.887.0(reference)
HLA-B amino acid position 199
 Val2.25.30.40 (0.30 to 0.54)1.80×10−7
 Ala97.894.7(reference)
HLA-DRβ1 amino acid position 28
 Glu18.929.50.57 (0.50 to 0.64)1.55×10−7
 His15.311.31.40 (1.20 to 1.62)2.76×10−1
 Asp64.358.7(reference)
  • *Amino acid residues with frequency ≥0.005 in the controls are shown.

  • †Obtained from the multivariate regression model that included position 205 in HLA-DPβ1, position 66 and 99 in HLA-B and position 28 in HLA-DRβ1 identified by stepwise regression analysis.