Table 1

Germline mutations in epithelial ovarian cancer

GeneFrequency in ovarian cancerLifetime risk
Hereditary breast and ovarian cancer
(BRCA1, BRCA2)
15%–21%8 9 17%–44%10
Lynch syndrome
(MLH1, MSH2 (EPCAM), MSH6, PMS2)
0.5%8 9 6%–12%12
Additional genes
(BRIP1, RAD51C, RAD51D)
2.5%–3%8 9 10%–15%9