Table 2

Association between polygenic risk scores (PRS) and ovarian cancer in different age groups

Age groupOverallSerous
OR (95% CI)P valuesOR (95% CI)P values
All ages1.32 (1.21 to 1.45)5.38×10–10 1.43 (1.29 to 1.58)1.28×10–11
<601.29 (0.91 to 1.86)0.161.46 (1.01 to 2.17)0.05
60–691.28 (1.11 to 1.49)8.99×10–4 1.34 (1.14 to 1.59)4.51×10–4
≥701.36 (1.20 to 1.55)3.02×10–6 1.47 (1.26 to 1.72)7.10×10–7
Interaction1.00 (0.99 to 1.02)0.881.00 (0.98 to 1.02)0.95
  • In the overall PRS analysis, we used cases of any type of ovarian cancers and in the serous PRS analysis we used cases of serous ovarian cancer.