Associations of classical HLA alleles with Graves’ disease susceptibility in Han Chinese
| HLA allele | PLINK INFO | Allele frequency (%)* | OR (95% CI) | P values | ||
| Cases (n=1468) | Controls (n=1490) | Caucasian populations | ||||
| HLA-A*02:07 | 0.90 | 9.7 | 4.9 | 0.007 | 2.10 (1.70 to 2.59) | 2.07×10−12 |
| HLA-B*46:01 | 0.94 | 14.1 | 6.5 | 0.010 | 2.38 (1.99 to 2.86) | 8.78×10− 21 |
| HLA-C*01:02 | 1.02 | 18.4 | 10.9 | 3.432 | 1.83 (1.57 to 2.12) | 5.40×10−15 |
| HLA-DPA1*02:02 | 0.92 | 59.5 | 44.8 | 6.324 | 1.90 (1.70 to 2.12) | 1.76×10−31 |
| HLA-DPB1*05:01 | 0.92 | 44.0 | 31.3 | 1.927 | 1.90 (1.69 to 2.14) | 1.73×10−26 |
| HLA-DQA1*02:01 | 1.04 | 7.0 | 15.2 | 12.658 | 0.43 (0.36 to 0.51) | 1.93×10−21 |
| HLA-DQB1*02:01 | 1.00 | 10.9 | 17.8 | 15.437 | 0.57 (0.49 to 0.66) | 2.31×10−13 |
| HLA-DRB1*07:01 | 1.04 | 7.1 | 15.3 | 13.337 | 0.43 (0.36 to 0.51) | 2.49×10−21 |
*The allele frequency of Caucasian populations was calculated from the average frequencies of all samples of Caucasiod ethnic origin from database: http://www.allelefrequencies.net.23
HLA, human leucocyte antigen.