Clinical characteristics of the whole cohort
| Clinical characteristic | n=1405* |
| AIP mutation, n (%) | 134 (9.5) |
| Familial, n (%) | 607 (43.2) |
| Gender, n (% male) | 680 (48.5) |
| Diagnosis, n (%) | |
| GH excess | 767 (55.5) |
| NFPA | 185 (13.4) |
| Prolactinoma | 344 (24.9) |
| Cushing’s disease | 74 (5.4) |
| Other diagnosis | 11 (0.8) |
| Age of onset (years) | 27.1±13.1 |
| Age at diagnosis (years) | 30.8±13.4 |
| Macroadenoma, n (%) | 977 (81.5) |
| Extrasellar extension, n (%) | 446 (60.1) |
| Pituitary apoplexy, n (%) | 48 (3.9) |
↵*Prospectively diagnosed patients excluded.
NFPA, non-functioning pituitary adenoma.