Gender | Fabry disease | Light microscopy | Electron microscopy | Immunofluorescence* | ||||||||
GS (%) | FSGS (%) | Interstitial fibrosis | Tubular atrophy | Gb-containing deposits | Ig G | IgM | IgA | C3 | C4 | C1q | ||
M/24 | Classical | 5% | 0% | − | − | G epi (4), T epi (4), P epi (4), A endo (3), A wall (3), G endo (3) | - | - | - | M (2) | - | - |
M/31 | Classical | 0% | 0% | + | ± | G epi (4), T epi (3), G endo (2) | - | M (2) | p (1) | M (2), p (2), T (2) | p (1) | M (1) |
M/47 | Classical | 0% | 0% | + | − | G epi (3), T epi (3), G endo (2) | - | M (2) | M (1) | M (1) | - | - |
M/16 | Classical | 0% | 0% | − | + | G epi (4), T epi (4), P epi (2), A wall (1), G endo (2) | - | M (1) | - | - | - | - |
M/13 (SN1) | Classical | 0% | 0% | − | − | G epi (3), T epi (2), Ce ndo (2) | - | M (2) | - | - | - | - |
M/21 | Classical | 9% | 5% | + | + | G epi (3), T epi (1) | - | - | - | M (2) | - | - |
M/10 | Classical | 0% | 0% | − | − | G epi (4), T epi (3), G endo (2) | - | - | - | M (2) | - | - |
M/36 | Classical | 9% | 0% | + | + | G epi (4), T epi (4), C endo (3), G endo (3) | - | M (1) | - | M (1) | - | - |
M/16 (SN3) | Classical | 30% | 0% | − | − | G epi (4), C endo (3), G endo (2) | - | M (1) | - | - | - | M (1) |
M/19 | Classical | 87% | 0% | + | + | G epi (4), P epi (3), G endo (3) | - | - | - | M (2) | - | - |
M/43 | Classical | 0% | 0% | − | − | G epi (4), T epi (4), P epi (3), C endo (2), G endo (1) | - | M (1) | - | M (3) | - | - |
The location of each immune complex was confirmed by electron microscopic examination.
A, artery; C, capillary; endo, endothelial cell; epi, epithelial cell; FSGS, focal segmental glomerular sclerosis; G, glomerulus; GS, global sclerosis; M, mesangium; p, periphery; T, tubule.
Numbers in parentheses indicate density: 1, minimal; 2, small amount; 3, moderate amount; 4, large amount.