Table 3

Renal biopsy findings of 11 patients with Fabry disease

GenderFabry diseaseLight microscopyElectron microscopyImmunofluorescence*
GS (%)FSGS (%)Interstitial fibrosisTubular atrophyGb-containing depositsIg GIgMIgAC3C4C1q
M/24Classical5%0%G epi (4), T epi (4), P epi (4), A endo (3), A wall (3), G endo (3)---M (2)--
M/31Classical0%0%+±G epi (4), T epi (3), G endo (2)-M (2)p (1)M (2), p (2), T (2)p (1)M (1)
M/47Classical0%0%+G epi (3), T epi (3), G endo (2)-M (2)M (1)M (1)--
M/16Classical0%0%+G epi (4), T epi (4), P epi (2), A wall (1), G endo (2)-M (1)----
M/13 (SN1)Classical0%0%G epi (3), T epi (2), Ce ndo (2)-M (2)----
M/21Classical9%5%++G epi (3), T epi (1)---M (2)--
M/10Classical0%0%G epi (4), T epi (3), G endo (2)---M (2)--
M/36Classical9%0%++G epi (4), T epi (4), C endo (3), G endo (3)-M (1)-M (1)--
M/16
(SN3)
Classical30%0%G epi (4), C endo (3), G endo (2)-M (1)---M (1)
M/19Classical87%0%++G epi (4), P epi (3), G endo (3)---M (2)--
M/43Classical0%0%G epi (4), T epi (4), P epi (3), C endo (2), G endo (1)-M (1)-M (3)--
  • The location of each immune complex was confirmed by electron microscopic examination.

  • A, artery; C, capillary; endo, endothelial cell; epi, epithelial cell; FSGS, focal segmental glomerular sclerosis; G, glomerulus; GS, global sclerosis; M, mesangium; p, periphery; T, tubule.

  • Numbers in parentheses indicate density: 1, minimal; 2, small amount; 3, moderate amount; 4, large amount.