Table 5

Validation of the Manchester Scoring System using samples from the Genetic Testing in Epithelial Ovarian Cancer study from Cambridge

Manchester score0–14
(0%–9.9%)
15–19
(10%–19.9%)
20–2425+Sensitivity at 10% (15–19) thresholdSpecificity at 10% threshold
Previous MSS25/170 (2.9%)0/23 (0%)7/26 (27%)5/12 (41.7%)12/17 (70.6%)97.1%
New MSS32/133 (1.5%)3/56 (5.4%)6/24 (25%)6/18 (33%)15/17 (88.2%)98.5%
BOADICEA*0%–9.9%10%–19.9%20%–29.9%30%+Sensitivity at 10% thresholdSpecificity
12/221 (5.5%)2/3 (67%)1/3 (33%)2/2 (100%)5/17 (29.5%)94.5%
  • * Two cases without mutations did not generate a BOADICEA score.