Table 4

Application of original MSS1, current MSS2 and new pathology-adjusted Manchester score MSS3 to 4113 index cases from unrelated families affected by breast/ovarian cancer

Manchester score<1515–1920–2425–2930+Total mutationTotal tested% BRCA1 % BRCA2 %
BRCA1/2 Number tested% BRCA1/2 Number tested% BRCA1/2 Number tested% BRCA1/2 Number tested% BRCA1/2 Number tested%
ER− HER2+ original MSS10190.00100.021020.02633.32366.764812.548.324.2
ER− HER2+ current
MSS2
0280.02922.21616.72450.011100.064812.548.324.2
ER− HER2+ new
MSS3
0260.021118.21616.72450.011100.064812.548.324.2
ER+ HER2+ MSS11482.11283.632810.71175.9090.061304.610.853.8
ER+ HER2+ MSS22722.83329.41166.3050.0050.061304.610.853.8
ER+ HER2+ MSS32802.532810.71137.7080.0010.061304.610.853.8
TNT MSS13225012.8338937.1306645.5233174.2414787.215948332.912525.9347.0
TNT MSS2111378.02411920.23710136.6305752.6576982.615948332.912525.9347.0
TNT MSS371126.3138615.13912631.0296942.0719078.915948332.912525.9347.0
TNT<30000.042416.72450.03837.5131492.9225044.01938.036.0
TNT 30–393754.032015.0144630.4102050.0303878.96019930.25326.673.5
TNT 40–4932810.752718.5153938.592339.1222781.55414437.54027.8149.7
TNT 50+1911.121513.383622.261931.661154.5239025.61314.41011.1
HGSOC MSS2+1514010.774316.3102441.73837.53560.03822017.32913.294.1
HGSOC MSS3+0240.02015512.952025.0101758.83475.03822017.32913.294.1
All ovarian case MSS339633025511.83111427.23911035.58713962.619071426.612317.2679.4
All ovarian MSS1*182068.73425313.46526624.46623428.218230859.1365126728.822717.913810.9
Ovarian MSS2*182487.3232449.46926625.96820533.218730461.5365126728.822717.913810.9
All ovarian* MSS331342.23734910.65624722.77822434.819131361.0365126728.822717.913810.9
Ovarian path adjusted only confirmed ovarian cancer92144.23835710.66623727.88320939.716925067.6365126728.822717.913810.9
Breast-only MSS16513724.77470010.48944120.25518529.77015146.4352284912.41575.51956.8
Breast-only MSS24913163.7747899.48939622.55819130.48315752.9353284912.41575.51956.8
Breast-only MSS34312923.3667578.79543421.95619428.99317254.1353284912.41575.51956.8
Breast MSS3 with path avail339203.66362510.110341125.18424334.618028762.7463248618.61315.31445.8
Breast/ovarian path avail MSS17311656.39270913.012652524.010332531.720736157.3601308519.533510.92668.6
Breast/ovarian path avail MSS25611305.08278910.412848626.310931234.922636861.4601308519.533510.92668.6
Breast/ovarian path avail MSS3359953.58885910.212450924.411433034.524039261.2601308519.533510.92668.6
  • *All ovarian cases and those with ovarian cancer family history. Only cases with proven high grade were included where no further ovarian cancers were present in the family. +HGSOC, high-grade serous ovarian cancer; path avail, pathology available; TNT, triple-negative tumour.