Table 2

Adjusted regression analyses of all participants by sex

VariableBeta coefficient†95% CI‡p Value
(A) Men, interaction model, n=137, intercept=418.4 ms, adjusted R2=0.54
V205M29.319.2 to 39.4<0.001
L353L14.02.9 to 25.10.014
K897T5.7−19.3 to 30.70.651
V205M*L353L34.612.0 to 57.20.003
(B) Women, interaction model, n=282, intercept=444.3 ms, adjusted R2=0.28
V205M31.520.1 to 42.9<0.001
L353L10.0−0.6 to 20.60.064
K897T−4.2−16.1 to 7.60.481
V205M*L353L−14.5−42.6 to 13.70.312
V205M*K897T−27.2−43.1 to -11.30.001
L353L*K897T29.94.7 to 55.00.020
V205M*L353L*K897T−14.0−51.3 to 23.30.461
(C) Men and women, interaction model, n=419, intercept=422.3 ms, adjusted R2=0.40
V205M30.021.8 to 38.3<0.001
L353L11.23.1 to 19.30.007
K897T−0.6−11.7 to 10.50.914
V205M*L353L7.2−17.4 to 31.50.558
V205M*K897T−26.7−40.5 to −12.8<0.001
L353L*K897T19.3−6.5 to 45.10.142
V205M*L353L*K897T−25.9−60.0 to 8.20.136
  • †Beta coefficients from OLS linear regression representing the baseline (intercept) and change in QTc (ms). Model was adjusted for age, past and current alcohol abuse, QT-prolonging drug use, cardiovascular disease and indicator variable for interpolated QTc.

  • ‡95% CI using robust SEs.

  • QTc, corrected QT.