Table 1

Discovery, replication and combined results for the top SNPs at the 22q12.2 and 7p21.3 loci

Chromosome
Position (bp)
SNP (effect/alternate allele)
Sample setsEffect allele frequencyNumberOR (95% CI)p ValueI2phet
CasesControlsCasesControls
22
30 494 371
rs2412971 (G/A)
Discovery 10.6060.55094462371.26 (1.14 to 1.40)3.51E-6
Discovery 20.6160.55952057821.27 (1.12 to 1.45)0.00031
Combined discovery146412 0191.27 (1.17 to 1.37)6.99E-900.94
Replication0.6030.573156713671.14 (1.02 to 1.26)0.017
All combined303113 3861.22 (1.14 to 1.30)1.48E-961.10.11
7
7 488 601
rs10255201 (T/C)
Discovery 10.9150.88694462371.40 (1.18 to 1.66)8.28E-5
Discovery 20.9200.88452057821.52 (1.21 to 1.92)0.00019
Combined discovery146412 0191.44 (1.25 to 1.66)2.84E-700.56
Replication0.8800.884157113600.97 (0.82 to 1.13)0.68
All combined303513 3791.21 (1.09 to 1.35)0.0003392.70.00022
  • bp, base pair; I2, heterogeneity estimate; phet, p value from Cochran's Q test of heterogeneity.