SNP18 results by quintile in non-BRCA1/2 carriers
| Quintile | SNP18 PRS cut point | O | E | n | O/E OR (95% CI) |
|---|---|---|---|---|---|
| Prospective cases | |||||
| 1 | 42 | 37.6 | 300 | 1.14 (0.86–1.49) | |
| 2 | 0.78 | 34 | 44.9 | 286 | 0.72 (0.53–0.98) |
| 3 | 0.94 | 54 | 55.0 | 301 | 0.98 (0.76–1.24) |
| 4 | 1.11 | 57 | 60.7 | 286 | 0.92 (0.73–1.16) |
| 5 | 1.37 | 74 | 75.1 | 288 | 0.98 (0.80–1.18) |
| All cases | |||||
| 1 | 49 | 42.6 | 307 | 1.18 (0.91–1.51) | |
| 2 | 0.78 | 38 | 51.5 | 296 | 0.70 (0.52–0.93) |
| 3 | 0.94 | 58 | 60.2 | 299 | 0.95 (0.75–1.19) |
| 4 | 1.11 | 67 | 68.9 | 296 | 0.96 (0.78–1.18) |
| 5 | 1.37 | 82 | 84.2 | 296 | 0.96 (0.80–1.15) |
E, expected number of cases; n, total number of women (cases and controls) in quintile; O, number of cases; O/E OR, observed divided by expected OR; PRS, polygenic risk score; SNP18 cut point, lower limit of quantile.