Experimental approaches targeting myosin (derived from Ref. 24)
| Approach | Compound | Target | Function |
|---|---|---|---|
| Pharmacological | Blebbistatin (research tool only) | Myosin class II All heavy chain isoforms | Inhibitor |
| N-benzyl-p-toluene sulphonamide (research tool only) | Myosin class II Fast-skeletal heavy chain isoform | Inhibitor | |
| 2,3-butanedione monoxime (research tool only) | Myosin class II All heavy chain isoforms | Inhibitor | |
| MYK-461 (preclinical—MyoKardia) | Myosin class II ß/slow-cardiac heavy chain isoform | Inhibitor | |
| Omecamtiv Mecarbil (clinical trial—Cytokinetics) | Myosin class II ß/slow-cardiac heavy chain isoform | Activator | |
| CGP48506 (preclinical—Novartis) | Myosin class II ß/slow-cardiac heavy chain isoform | Activator | |
| EMD57033 (preclinical—Merck) | Myosin class II ß/slow-cardiac heavy chain isoform | Activator | |
| Genetic | MYL4 incorporation (preclinical) | Myosin class II Atrial/fetal essential light chain isoform | Activator |