Families with pathogenic mutation | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Families | BRCA1/2 | BRCA1 | BRCA2 | |||||||||
Group | Familial cancer history (including proband) | N | % of total | n | Prev (%) | 95% CI (%) | n | Prev (%) | 95% CI (%) | n | Prev (%) | 95% CI (%) |
Group 2a: OC only | 2 OC (no BC, mBC) | 194 | 0.9 | 79 | 40.7 | 34.1 to 47.8 | 50 | 25.8 | 20.1 to 32.4 | 29 | 14.9 | 10.6 to 20.6 |
≥3 OC (no BC, mBC) | 66 | 0.3 | 30 | 45.5 | 34.0 to 57.4 | 27 | 40.9 | 29.9 to 53.0 | 5 | 7.6 | 3.3 to 16.5 | |
Total | 260 | 1.2 | 109 | 41.9 | 36.1 to 48.0 | 77 | 29.6 | 24.4 to 35.4 | 34 | 13.1 | 9.5 to 17.7 | |
Group 2b: OC and female BC, but no mBC | 1 BC51+OC (no mBC) | 118 | 0.6 | 24 | 20.3 | 14.1 to 28.5 | 17 | 14.4 | 9.2 to 21.9 | 7 | 5.9 | 2.9 to 11.7 |
1 BC50−OC (no mBC) | 145 | 0.7 | 71 | 49.0 | 41.0 to 57.0 | 56 | 38.6 | 31.1 to 46.7 | 15 | 10.3 | 6.4 to 16.4 | |
≥2 BCOC (no mBC) | 11 | 0.1 | 7 | 63.6 | 35.4 to 84.8 | 7 | 63.6 | 35.4 to 84.8 | 0 | 0.0 | 0.0 to 25.9 | |
≥2 BCOC+≥1 BC/OC (no mBC) | 1482 | 6.9 | 796 | 53.7 | 51.2 to 56.2 | 641 | 43.3 | 40.8 to 45.8 | 160 | 10.8 | 9.3 to 12.5 | |
1 BC51++1 OC (no mBC, BCOC) | 333 | 1.6 | 64 | 19.2 | 15.3 to 23.8 | 39 | 11.7 | 8.7 to 15.6 | 26 | 7.8 | 5.4 to 11.2 | |
1 BC50−+1 OC (no mBC, BCOC) | 645 | 3.0 | 203 | 31.5 | 28.0 to 35.2 | 155 | 24.0 | 20.9 to 27.5 | 48 | 7.4 | 5.7 to 9.7 | |
1 BC+≥2 OC (no mBC, BCOC) | 248 | 1.2 | 113 | 45.6 | 39.5 to 51.8 | 100 | 40.3 | 34.4 to 46.5 | 13 | 5.2 | 3.1 to 8.8 | |
≥2 BC+≥1 OC (no mBC, BCOC) | 2090 | 9.8 | 833 | 39.9 | 37.8 to 42.0 | 609 | 29.1 | 27.2 to 31.1 | 231 | 11.1 | 9.8 to 12.5 | |
Total | 5072 | 23.7 | 2111 | 41.6 | 40.3 to 43.0 | 1624 | 32.0 | 30.7 to 33.3 | 500 | 9.9 | 9.1 to 10.7 | |
Group 3: mBC | 1 mBC+1 BC51+ (no OC) | 97 | 0.5 | 16 | 16.5 | 10.4 to 25.1 | 3 | 3.1 | 1.1 to 8.7 | 13 | 13.4 | 8.0 to 21.6 |
1 mBC+1 BC50− (no OC) | 99 | 0.5 | 23 | 23.2 | 16.0 to 32.5 | 5 | 5.1 | 2.2 to 11.3 | 18 | 18.2 | 11.8 to 26.9 | |
1 mBC+≥2 BC (no OC) | 331 | 1.5 | 128 | 38.7 | 33.6 to 44.0 | 29 | 8.8 | 6.2 to 12.3 | 100 | 30.2 | 25.5 to 35.4 | |
≥2 mBC+≥1 BC (no OC) | 23 | 0.1 | 15 | 65.2 | 44.9 to 81.2 | 1 | 4.3 | 0.8 to 21.0 | 15 | 65.2 | 44.9 to 81.2 | |
1 mBC+≥1 OC (no BC) | 15 | 0.1 | 8 | 53.3 | 30.1 to 75.2 | 4 | 26.7 | 10.9 to 52.0 | 4 | 26.7 | 10.9 to 52.0 | |
≥1 mBC+≥1 BC +≥1 OC | 77 | 0.4 | 40 | 51.9 | 41.0 to 62.7 | 18 | 23.4 | 15.3 to 34.0 | 23 | 29.9 | 20.8 to 40.8 | |
Total | 642 | 3.0 | 230 | 35.8 | 32.2 to 39.6 | 60 | 9.3 | 7.3 to 11.8 | 173 | 26.9 | 23.7 to 30.5 |
Prev, prevalence.