Family characteristics
| Total | BRCA1 | BRCA2 | Negative | |
|---|---|---|---|---|
| Families, no | 21 401 | 3398 | 1766 | 16 265 |
| Members | ||||
| Total number | 617 578 | 99 708 | 52 861 | 466 013 |
| Median per family | 25 | 26 | 26 | 25 |
| Members with cancer, no | ||||
| uBC50− | 26 236 | 4996 | 2519 | 18 770 |
| uBC51+ | 24 452 | 2789 | 2033 | 19 655 |
| bBC50− | 4132 | 1304 | 427 | 2414 |
| bBC51+ | 1896 | 239 | 168 | 1492 |
| OC | 7250 | 2650 | 730 | 3897 |
| BC and OC | 1917 | 805 | 202 | 916 |
| Male BC | 671 | 62 | 193 | 420 |
| Age of onset (mean)* | ||||
| BC | 49.0 | 44.4 | 47.5 | 50.2 |
| OC | 51.5 | 49.8 | 55.6 | 51.9 |
| Male BC | 58.0 | 56.9 | 60.4 | 57.0 |
*Mean ages of onset for BC and OC were significantly different in all pairwise group comparisons (p<0.001). For male BC, mean age of onset was significantly different between BRCA2-positive and BRCA1/2-negative families (p=0.006).
bBC, bilateral breast cancer; BC, breast cancer; OC, ovarian cancer.