Table 3

OR estimates and p-values for case–control screening of 18 Breast Cancer Association Consortium SNPs

Control%Case%Adjusted ORCI*p>|z|
Utilizing NPS as a continuous score
 All105710012361005.76×10−10
 Only Caucasians90485.578863.83.47×10−10
 Excluding Caucasian15314.544836.30.32
Number of subjects at risk indicated by NPS score above Threshold group
 All†131.2262.12.561.26 to 5.190.009
 Only Caucasian†121.3253.23.021.45 to 6.290.003
 Excluding CaucasianNever≥2.5
OR of top and bottom percentiles using middle quintile as reference
 All
 0–1%111.050.40.500.16 to 1.560.232
 1–5%424.0282.30.720.42 to 1.240.239
 95–99%413.9735.91.991.27 to 3.120.003
 99–100%111.0221.82.741.27 to 5.900.010
Only Caucasian
 0–1%101.130.40.480.13 to 1.810.278
 1–5%364.0192.40.800.44 to 1.480.482
 95–99%364.0516.52.001.22 to 3.260.006
 99–100%101.1222.83.201.45 to 7.080.004
  • *Adjusted for study centre and race/ethnicity.

  • †NPS≥2.1. NPS, normalised polygene score.