Countries | No. of patients, n | BRCA1 mutation, n (%) | BRCA2 mutation, n (%) | BRCA1/BRCA2 mutations, n (%) | Age of early onset, n (%) | Family history of breast cancer and/or ovarian cancer, n (%) | Triple negative, n (%) | Bilateral breast cancer, n (%) | References |
---|---|---|---|---|---|---|---|---|---|
Hong Kong | 50 | 21 (42) | 29 | – | <35 years, 50 | 25 | – | 13 (26) | 70 |
130 | 5 (3.8) | – | – | <45 years, 56 (43) | – | 71 | |||
451 | 29 (6.4) | 40 (8.9) | <40 years, 155 (34.4) | 193/318 (60.7) | 68/377 (18.0) | 72 (16.0) | 14 | ||
Korea | 2139 | 127 (5.9) | 137 (6.4) | – | – | – | – | 52 | |
841 | 74 (8.8) | 89 (10.6) | 3 (0.4) | – | – | – | 69 | ||
354 | 17 (4.8) | 8 (2.3) | – | <35 years; 152 (42.9) | – | – | 39 (11.0) | 72 | |
60 | – | – | 5 (8.3) | <35 years; 35 (58) | 8 (13) | – | 73 | ||
173 | 15 (8.7) | 7 (4) | – | <35 years; 74 (42.8) | 86 (49.7) | – | 66 | ||
758 | 25 (3.3) | 40 (5.3) | – | <40 years; 550 (72.6) | – | – | 67 (8.8) | 26 | |
China | 139 | 6 (4.3) | – | – | <35 years; 4 (2.8) | 8 (5.8) | 25 (18) | 10 | |
448 | 20 (4.5) | 21 (4.7) | – | <35 years; 22/253 (8.7) | 31/241 (12.9) | 78 (17.4) | 13 | ||
70 | 6 (8.6) | 2 (2.9) | – | <35 years; 42 (60) | 5 (7.1) | – | 12 | ||
645 | 54 (8.4) | 73 (11.3) | 123 (19.1) | <45 years; 256 (39.7) | 28 (4.3) | – | 74 | ||
360 | 52 (14.4) | 28 (7.8) | – | – | 76 (21.1) | 75 | |||
96 | 18 (18.6) | 7 (7.3) | – | <35 years; 26 (27.1) | 28 (29.1) | 96 (100) | 76 | ||
409 | 16 (3.9) | 27 (6.6) | – | <40 years; 78 (19.1) | 375 (91.7) | 96 (23.5) | 34 (8.3) | 11 | |
Vietnam | 292 | – | – | 24 (0.8) | <40 years; 46 (15.8) | 7 (2.4) | – | 9 | |
Malaysia | 44 | 1 (2.3) | 5 (11.4) | – | <40 years; 24 (54.5) | 20 (45.5) | – | 28 | |
431 | 37 (8.6) | 28 (6.5) | – | <35 years; 131 (30.4) | 236 (54.7) | 110 (25.5) | 39 (9.0) | 77 | |
Singapore | 70 | 6 (8.6) | – | – | <35 years; 22 (31.4) | 16 (22.9) | – | 35 | |
43 | 7 (16.3) | – | – | <30 years; 7 (16.3) | 7 (16.3) | – | 78 | ||
Singapore-Malay | 50 | 9 (18) | – | – | <35 years; 11 (22) | 8 (16) | – | 54 | |
49 | 6 (12.2) | – | – | <40 years, 19 (38.8) | – | – | 79 |