Association between protein truncating variants in BRIP1 and breast cancer risk by subtype
| ER-positive | ER-negative | Triple negative | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Study | Carrier/total (%) | OR (95% CI) | p Value | Carrier/total (%) | OR (95% CI) | p Value | Carrier/total (%) | OR (95% CI) | p Value |
| BCAC | 4/27,680 (0.01%) | 0.38 (0.13 to 1.15) | 0.09 | 8/7707 (0.10%) | 2.25 (0.93 to 5.46) | 0.07 | 4/2983 (0.13%) | 3.62 (0.99 to 13.2) | 0.05 |
| SEARCH | 14/7391 (0.19%) | 0.76 (0.36 to 1.63) | 0.56 | 2/1521 (0.13%) | 0.53 (0.06 to 2.34) | 0.54 | 1/551 (0.18%) | 0.73 (0.02 to 4.89) | 1.0 |
| Combined | 0.61 (0.33 to 1.13) | 0.12 | 1.71 (0.77 to 3.80) | 0.19 | 2.71 (0.84 to 8.74) | 0.10 | |||
BCAC, Breast Cancer Association Consortium; ER, oestrogen receptor.