Table 1

Inclusion criteria for BRCA1/BRCA2 genetic testing by research groups in different countries (any one of the risk factors)

Location*Early onset of breast cancer (age)Ovarian cancerBilateral breast cancerMale breast cancerTriple-negative breast cancerFamily history and other risk factorsReferences
Bangladesh<40 yearsUnselected for family history9
China, Beijing<35 yearsBilateral, age <50 yearsAt least one first-degree or second-degree relative with breast and/or ovarian cancer, regardless of age10 11
China, Shanghai<35 yearsAt least one first-degree or second-degree relative with breast and/or ovarian cancer, regardless of age
At least one first-degree relative with malignant tumour beyond breast and ovarian cancer
12 13
Hong Kong<45 yearsYesBilateralYesYesAt least one first-degree or second-degree relative with breast and/or ovarian cancer, regardless of age14
India†<35–40 yearsYesYesFamily history of breast and/or ovarian cancer†15–18
Indonesia<40 yearsBilateralDiagnosed age <50 years, with at least one first-degree or second-degree relative with breast or ovarian cancer, regardless of age
At least two first-degree or second-degree relatives with breast cancer
19
Iran†<35–45 yearsYesTwo breast primariesYesFamily history of breast and/or ovarian cancer†
With multiple organ cancers including breast
20–22
Iraq, Syria, and Yemen<40 years<45 yearsAt least two first-degree or second-degree relatives with breast or ovarian cancer
At least one relative with breast and ovarian cancer
23
IsraelYesAsymptomatic women from high-risk breast/ovarian cancer families2424 25
Japan<45 yearsYesBilateral, age <50 yearsYesDiagnosed age <50 years, with at least one close relative with breast cancer <50 years, or one close relative with ovarian cancer, regardless of age
At least two close relatives with breast cancer and/or ovarian cancer, regardless of age
Korea<40 yearsYesBilateralYesWith family history of breast or ovarian cancer
With multiple organ cancers including breast
26
LebanonYesYesAt least one relative with breast cancer under age of 50 years
At least two first-degree or second-degree relatives with breast cancer and/or ovarian cancer
27
Malaysia<35 yearsYesBilateralYesAt least one relative with breast cancer under age of 35 years, male breast cancer, or multiple cancers
At least two relatives with breast or ovarian cancer, and at least one diagnosed at age <50 years
At least three relatives with breast or ovarian cancer
28 29
Oman<40 yearsBilateralYes30
Pakistan†<30 yearsYes, age<45 yearsYesAt least two first-degree or second-degree (through a male) female relatives with breast cancer, and at least one diagnosed at age <50 years
At least three relatives with breast cancer, and at least one diagnosed at age <50 years
At least one relative with breast and ovarian cancer
31–33
Philippines<50 yearsYesBilateralYesAt least two relatives with breast or ovarian cancer
At least one relative with two primaries, both breast and ovarian cancer, or multiple cancers
34
Singapore†<40 yearsYesTwo breast primariesAt least one close relative with breast and/or ovarian cancer
priori risk of 10% (BRCAPRO model)†
35–37
Taiwan<35 yearsBilateralDiagnosed age <50 years, with at least one close relative with breast cancer or ovarian cancer
At least three relatives with breast cancer or one with ovarian cancer
38 39
Thailand†YesYesAt least two first-degree relatives with breast cancer and/or ovarian cancer33 40
Turkey†<40–50 yearsYesBilateralYesFamily history of breast and/or ovarian cancer†
Patients with prostate cancer with family history of breast cancer, ovarian cancer, or prostate cancer
41–45
VietnamUnselectedUnselected for family history9
USA/Canada<45 yearsYesBilateral, age <50 yearsYesDiagnosed age <50 years, with at least one close relative with breast cancer <50 years, or one close relative with ovarian cancer, regardless of age
At least two close relatives with breast cancer and/or ovarian cancer, regardless of age
Ethnicity associated with higher mutation frequency (eg, Ashkenazi Jewish)
  • *No information of BRCA1/BRCA2 mutation was found in Afghanistan, Kazakhstan and other Asian countries.

  • †Criteria varied among different research groups in the country.