Table 1

Inclusion criteria for BRCA1/BRCA2 genetic testing by research groups in different countries (any one of the risk factors)

Location*	Early onset of breast cancer (age)	Ovarian cancer	Bilateral breast cancer	Male breast cancer	Triple-negative breast cancer	Family history and other risk factors	References
Bangladesh	<40 years					Unselected for family history	9
China, Beijing	<35 years		Bilateral, age <50 years			At least one first-degree or second-degree relative with breast and/or ovarian cancer, regardless of age	10 11
China, Shanghai	<35 years					At least one first-degree or second-degree relative with breast and/or ovarian cancer, regardless of age At least one first-degree relative with malignant tumour beyond breast and ovarian cancer	12 13
Hong Kong	<45 years	Yes	Bilateral	Yes	Yes	At least one first-degree or second-degree relative with breast and/or ovarian cancer, regardless of age	14
India†	<35–40 years	Yes		Yes		Family history of breast and/or ovarian cancer†	15–18
Indonesia	<40 years		Bilateral			Diagnosed age <50 years, with at least one first-degree or second-degree relative with breast or ovarian cancer, regardless of age At least two first-degree or second-degree relatives with breast cancer	19
Iran†	<35–45 years	Yes	Two breast primaries	Yes		Family history of breast and/or ovarian cancer† With multiple organ cancers including breast	20–22
Iraq, Syria, and Yemen	<40 years	<45 years				At least two first-degree or second-degree relatives with breast or ovarian cancer At least one relative with breast and ovarian cancer	23
Israel		Yes				Asymptomatic women from high-risk breast/ovarian cancer families24	24 25
Japan	<45 years	Yes	Bilateral, age <50 years	Yes		Diagnosed age <50 years, with at least one close relative with breast cancer <50 years, or one close relative with ovarian cancer, regardless of age At least two close relatives with breast cancer and/or ovarian cancer, regardless of age
Korea	<40 years	Yes	Bilateral	Yes		With family history of breast or ovarian cancer With multiple organ cancers including breast	26
Lebanon		Yes		Yes		At least one relative with breast cancer under age of 50 years At least two first-degree or second-degree relatives with breast cancer and/or ovarian cancer	27
Malaysia	<35 years	Yes	Bilateral	Yes		At least one relative with breast cancer under age of 35 years, male breast cancer, or multiple cancers At least two relatives with breast or ovarian cancer, and at least one diagnosed at age <50 years At least three relatives with breast or ovarian cancer	28 29
Oman	<40 years		Bilateral		Yes		30
Pakistan†	<30 years	Yes, age<45 years		Yes		At least two first-degree or second-degree (through a male) female relatives with breast cancer, and at least one diagnosed at age <50 years At least three relatives with breast cancer, and at least one diagnosed at age <50 years At least one relative with breast and ovarian cancer	31–33
Philippines	<50 years	Yes	Bilateral	Yes		At least two relatives with breast or ovarian cancer At least one relative with two primaries, both breast and ovarian cancer, or multiple cancers	34
Singapore†	<40 years	Yes	Two breast primaries			At least one close relative with breast and/or ovarian cancer priori risk of 10% (BRCAPRO model)†	35–37
Taiwan	<35 years		Bilateral			Diagnosed age <50 years, with at least one close relative with breast cancer or ovarian cancer At least three relatives with breast cancer or one with ovarian cancer	38 39
Thailand†	Yes	Yes				At least two first-degree relatives with breast cancer and/or ovarian cancer	33 40
Turkey†	<40–50 years	Yes	Bilateral	Yes		Family history of breast and/or ovarian cancer† Patients with prostate cancer with family history of breast cancer, ovarian cancer, or prostate cancer	41–45
Vietnam	Unselected					Unselected for family history	9
USA/Canada	<45 years	Yes	Bilateral, age <50 years	Yes		Diagnosed age <50 years, with at least one close relative with breast cancer <50 years, or one close relative with ovarian cancer, regardless of age At least two close relatives with breast cancer and/or ovarian cancer, regardless of age Ethnicity associated with higher mutation frequency (eg, Ashkenazi Jewish)

*No information of BRCA1/BRCA2 mutation was found in Afghanistan, Kazakhstan and other Asian countries.
†Criteria varied among different research groups in the country.