Table 2

Metabolic parameters analysed in WBS mice models at 25 weeks of age

WTCDDDPD
Age (weeks)26.27±0.826.11±0.625.7±1.2525.44±1.74
Triglycerides (mg/dL)
(no. mice)
99.4±9.97
(8)
104.1±21.67
(8)
83.91±12.41
(7)
84.38±14.4
(4)
Total cholesterol (mg/dL)
(no. mice)
117.1±28.16
(15)
123.6±6.61
(7)
131.48±16.8
(10)
124.6±18.6
(10)
Total bilirubin (mg/dL)
(no. mice)
0.617±0.343
(13)
0.506±0.211
(4)
0.45±0.25
(6)
0.471±0.221
(6)
Direct bilirubin (mg/dL)
(no. mice)
0.419±0.36
(13)
0.303±0.15
(4)
0.158±0.086
(6)
0.202±0.126
(6)
Indirect bilirubin (mg/dL)
(no. mice)
0.198±0.137
(13)
0.204±0.117
(4)
0.293±0.200
(6)
0.269±0.116
(6)
Total protein (mg/dL)
(no. mice)
4791±314
(14)
4747±422
(12)
4894±333
(10)
5015±161
(12)
Glucose (mg/dL)
(no. mice)
173.9±49.9
(12)
167.8±41.1
(8)
189.6±59.9
(8)
157±52.8
(3)
TSH (uIU/mL)
(no. mice)
0.142±0.014
(5)
0.116±0.063
(3)
0.193±0.032
(3)
0.223±0.054*
(6)
  • All values are mean±SD. Asterisks represent significant differences of at least p<0.006 (after Bonferroni's correction) compared with WT mice.

  • CD, complete deletion; DD, distal deletion; PD, proximal deletion; TSH, thyroid-stimulating hormone; WBS, Williams–Beuren syndrome; WT, wild-type.