Table 2

Nagelkerke's R-squared (R2) values for the different data splits

R2
Excluding HLA
R2
Including HLA*
Single-SNPs
 Split A0.2550.340
 Split B0.1850.291
SNP-haplotypes
 Split A0.4180.482
 Split B0.2890.377
HLA alone
 Split A0.130
 Split B0.133
  • *The HLA models were based on previously published allelic associations4 ,6 ,7 in addition to an association with the DQB1*0502 allele (see online supplementary material). Consequently the same set of alleles and allelic interactions was used for both splits.

  • HLA, human leucocyte antigen; SNP, single nucleotide polymorphism.