Association between missense variants in BRIP1 with Combined Annotation-Dependent Depletion score >20 and breast cancer risk
| Study | Case carriers/total (%) | Control carriers/total (%) | OR (95% CI) | p Value |
|---|---|---|---|---|
| BCAC | 429/47,666 (0.90%) | 370/43,176 (0.86%) | 1.06 (0.92 to 1.22) | 0.43 |
| SEARCH | 276/13,213 (2.1%) | 107/5242 (2.0%) | 1.06 (0.85 to 1.32) | 0.66 |
| BCFR | 0/1313 (0%) | 1/1123 (0.09%) | – | |
| PeterMac | 40/1853 (2.2%) | 28/2001 (1.4%) | 1.68 (1.02 to 2.82) | 0.03 |
| Combined | 1.08 (0.95 to 1.24) | 0.25 |
BCAC, Breast Cancer Association Consortium; BCFR, Breast Cancer Family Registry.