Table 1

Chromosome 6 (long arm) associations*

SNPs†HaplotypeControl
Neg
Control
Pos
Case
Neg
Case
Pos
ORp Value‡
Single-SNPs
 rs11154801_A1759210 908421271521.24 (1.18 to 1.30)2×10−18
 rs1475069_C194449299503660321.22 (1.16 to 1.28)3×10−16
Multiple SNPs
 rs7739635 _A
 rs10223338_A
 rs12202212_A
 rs1475069_C000100018 6163410 8151758.9 (6.1 to 13.2)5×10−44
 rs2038551_A
 rs9399161_G
 rs4896180_G
  • The SNP rs11154801_A is the top single-SNP ‘hit’ in the region. The SNP rs1475069_C is the top single-SNP ‘hit’ within the multi-SNP-haplotype but the fourth most significant single-SNP ‘hit’ overall. These two SNPs are separated by 317 kb of DNA. The 95% CIs for the OR are shown in parentheses.

  • *In all cases the model selected was dominant.  

  • †Letters designate the minor allele nucleotide at the SNP location in the control population. Thus, the letters, which follow each SNP’s so-called ‘rs ID’ number, indicate the allele that was designated as the ‘1’ allele.

  • ‡The p values presented have not been corrected for the total number of SNP-haplotypes or single-SNPs tested. The total number of SNP-haplotypes (of any length from 1 to 15 SNPs) was 110 310. Therefore, the Bonferroni-corrected p value for the multi-SNP-haplotype is 6×10−39, which is still well below the uncorrected p value for the single-SNP.

  • SNP, single nucleotide polymorphism.