Table 3

The associations of genetic variants from fine mapping analysis in 1q32.1 with melanoma overall survival

					Conditioned by rs3024493 genotype
SNP	Position	Genotype	HR (95% CI)	p Value	HR (95% CI)	p Value
rs3024493		GG	Ref		Ref
	chr1:206943968	GT	0.58 (0.39 to 0.86)		–
		TT	4.73 (1.68 to 13.29)	0.00069	–	1
rs3024491		GG	Ref		Ref
	chr1:206945046	GT	0.56 (0.37 to 0.87)		0.75 (0.42 to 1.06)
		TT	0.47 (0.27 to 0.82)	0.0086	0.54 (0.28 to 1.07)	0.13
rs2222202		CC	Ref		Ref
	chr1:206945381	CT	0.58 (0.40 to 0.84)		0.59 (0.36 to 0.97)
		TT	0.50 (0.31 to 0.81)	0.0042	0.41 (0.20 to 0.86)	0.03
rs1800896		AA	Ref		Ref
	chr1:206946897	AG	0.54 (0.35 to 0.83)		0.64 (0.40 to 1.02)
		GG	0.49 (0.29 to 0.83)	0.0067	0.56 (0.29 to 1.08)	0.11
rs1800890		TT	Ref		Ref
	chr1:206949365	TA	0.49 (0.32 to 0.74)		0.57 (0.34 to 0.96)
		AA	0.46 (0.24 to 0.88)	0.00082	0.38 (0.16 to 0.92)	0.028
rs1028182		CC	Ref		Ref
	chr1:207001879	CT	1.66 (1.11 to 2.48)		1.61 (1.07 to 2.43)
		TT	0.74 (0.31 to 1.78)	0.022	0.57 (0.23 to 1.42)	0.012
rs960326		AA	Ref		Ref
	chr1:207014776	AG	2.19 (1.39 to 3.45)		2.13 (1.34 to 3.37)
		GG	2.90 (0.67 to 12.57)	0.0032	3.04 (0.69 to 13.4)	0.0048
rs1400986		CC	Ref		Ref
	chr1:207038686	CT	1.52 (1.07 to 2.15)		1.80 (1.16 to 2.79)
		TT	0.71 (0.22 to 2.29)	0.041	0.44 (0.059 to 3.30)	0.016

The results of association analysis of 24 SNPs selected for fine mapping of 1q32.1 associations with melanoma overall survival in 1022 melanoma patients ascertained at NYU Medical Center. The associations, HRs and 95% CIs were calculated using Cox regression models under two degrees of freedom test, adjusted by age at diagnosis, gender, stage, thickness, ulceration and histological subtype. Last columns show the association results conditioned on genotypes of rs3024493.
p Values were determined using two degrees of freedom test.
SNP, single nucleotide polymorphism.