Table 2

Summary of genotype profile by tumour location for cases with germline and tumour DNA available

Location	Total N=145	Germline mutation N=46	p Value Germline vs somatic mutation	Somatic mutation N=43	Total mutated N=89	p Value Mutated vs non-mutated	Non-mutated N=56
PCC	77	9	6.67×10⁻⁸	33	42	NS	35
PGL	68	37	6.67×10⁻⁸	10	47	NS	21
HN-PGL	24	15	2.0×10⁻⁴	1	16	NS	8
T-PGL	7	6	0.027	0	6	NS	1
A-PGL	37	16	NS	9	25	NS	12
TA-PGL	44	22	0.0078	9	31	NS	13

A-PGL, abdominal PGL; HN-PGL, head and neck PGL; NS, not statistically significant; PCC, pheochromocytoma; PGL, paraganglioma; T-PGL, thoracic-PGL; TA-PGL, thoracic plus abdominal-PGL; vs, versus.