Biochemical parameters studied in individuals with WBS
| Biochemical parameter | Total individuals assessed no. (%) | Z-score (mean±SD) | Centiles (%) | ||
|---|---|---|---|---|---|
| <p2.5 (%) | p2.5–97.5 (%) | >p97.5 (%) | |||
| TSH | 83/154 (53.9%) | 1.158±1.78 | 0 | 68.7 | 31.3 |
| Glucose | 151/154 (98.1%) | 0.642±2.261 | 2.0 | 90.7 | 7.3 |
| Triglycerides* | 115/154 (74.7%) | −0.146±0.887 | 18.3* | 79.1 | 2.6* |
| Total cholesterol* | 129/154 (83.8%) | −0.194±0.978 | 12.4* | 83.7 | 3.9* |
| Total bilirubin | 89/154 (57.8%) | 0.499±2.47 | 1.1 | 78.7 | 20.2 |
| Direct bilirubin | 53/154 (34.4%) | −0.161±1.26 | 5.7 | 86.8 | 7.5 |
| Indirect bilirubin | 53/154 (34.4%) | 2.08±5.09 | 0 | 66 | 34 |
| Iron | 70/154 (45.5%) | 0.715±2.471 | 7.1 | 66.7 | 21.4 |
| Transferrin | 69/154 (44.8%) | 0.378±0.851 | 0 | 95.7 | 4.3 |
| Total protein | 88/154 (57.1%) | 1.13±1.25 | 0 | 72.7 | 27.3 |
| Albumin | 73/154 (47.4%) | 0.96±0.886 | 0 | 89 | 11 |
Mean Z-score value, percentage of individuals below the 2.5th centile, between the 2.5th and 97.5th centile and above the 97.5th centile.
*For triglycerides and total cholesterol, percentage of individuals below the 5th centile, between the 5th and 95th centile and above the 95th centile.
TSH, thyroid-stimulating hormone; WBS, Williams–Beuren syndrome.