Association of DCAF4 rs2535913 minor allele with leucocyte telomere length in discovery and replication cohorts
| Analysis | N | MAF | β (SE) | SE | p Value | I2* (%) | Het p† |
|---|---|---|---|---|---|---|---|
| Discovery | 9190 | 0.3091 | −0.0554‡ | 0.011 | 2×10−7 | 18 | 0.30 |
| Replication 1 (de novo genotyped data set) | 3037 | 0.2743 | −0.0343‡ | 0.018 | 6.13 ×10−2 | 29 | 0.24 |
| Combined (discovery+replication 1) | 12 227 | 0.2991 | −0.0505‡ | 0.009 | 2.31×10−8 | 21 | 0.25 |
| Replication 2 (qPCR data set) | 7795 | 0.3144 | −0.0451§ | 0.017 | 7.84×10−3 | 0 | 0.70 |
| Combined (all) | 20 022 | 0.3061 | −0.0493¶ | 0.008 | 6.38×10−10 | 0 | 0.46 |
*Heterogeneity index I2 by Higgins et al.35
†Cochran’s heterogeneity statistic’s p value.
‡Effect reported in kb relative to the minor allele.
§Effect reported in (T/S) ratio relative to the minor allele.
¶Effect reported for the inverse-variance random-effect meta-analysis.