Number of mutation carriers predicted by each model and comparison with observed numbers
| Model for the residual familial aggregation | Observed BRCA1 carriers | Expected BRCA1 carriers | Observed BRCA2 carriers | Expected BRCA2 carriers | χ2 value* |
|---|---|---|---|---|---|
| Baseline | 44 | 56.95 | 62 | 63.59 | 2.98 |
| Polygenic | 44 | 49.32 | 62 | 61.98 | 0.57 |
| Dominant major | 44 | 55.62 | 62 | 63.08 | 2.45 |
| Recessive major | 44 | 55.97 | 62 | 63.11 | 2.58 |
| General major | 44 | 55.62 | 62 | 63.08 | 2.45 |
| Dominant mixed | 44 | 48.07 | 62 | 61.01 | 0.36 |
| Recessive mixed | 44 | 49.08 | 62 | 61.10 | 0.54 |
| General mixed | 44 | 48.05 | 62 | 61.02 | 0.36 |
| BOADICEA | 44 | 45.76 | 62 | 23.03 | 66.01 |
*χ2 value, value of χ2 goodness-of-fit test.
BOADICEA, Breast and Ovarian Analysis of Disease Incidence and Carrrier Estimation Algorithm.