Table 2

Number of mutation carriers predicted by each model and comparison with observed numbers

Model for the residual familial aggregationObserved BRCA1 carriersExpected BRCA1 carriersObserved BRCA2 carriersExpected BRCA2 carriersχ2 value*
Dominant major4455.626263.082.45
Recessive major4455.976263.112.58
General major4455.626263.082.45
Dominant mixed4448.076261.010.36
Recessive mixed4449.086261.100.54
General mixed4448.056261.020.36
  • 2 value, value of χ2 goodness-of-fit test.

  • BOADICEA, Breast and Ovarian Analysis of Disease Incidence and Carrrier Estimation Algorithm.